Immunogenicity of inactivated COVID-19 vaccine in patients with autoimmune inflammatory rheumatic diseasesArticle Published on 2022-10-262022-11-15 Journal: Scientific Reports [Category] 진단, [키워드] antibody antibody unit Autoimmune comparable control group COVID-19 vaccine COVID-19 vaccine development defined dose Efficacy General population HCQ IgG IgG antibodies IgG antibody immunogenic immunogenicity immunomodulatory medications inactivated Inflammatory low dose median MTX no difference Patient patients treated positive serum antibodies Progress Protein reduced rheumatic disease second vaccination Seropositivity serum IgG significantly SLE statistical significance statistically significant suppressed treated [DOI] 10.1038/s41598-022-22839-0 PMC 바로가기
Artificial Cell Membrane Polymersome-Based Intranasal Beta Spike Formulation as a Second Generation Covid-19 VaccineArticle Published on 2022-10-252022-11-15 Journal: ACS Nano [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] ACM acute respiratory syndrome adverse effect airway antibodies antibody antigen presenting cells artificial Beta Beta spike C57BL/6 cell membrane clinical symptom clinical trial component conditions coronavirus coronavirus disease COVID-19 CpG cross-neutralizing current delivery of cargo dendritic cells dose doses evaluate evaluated Formulation generate Generation Good hamster hamsters immune responses immunization immunogenic induce Infection initiated interval intranasal mice neutralize neutralizing antibody neutralizing responses New omicron Phase 1 polymersome Practice PROTECT reduction repeated Safety SARS-CoV-2 second serum IgG spike Spike protein Spike-based vaccine Support Toxicity upper respiratory tract Vaccine vaccine. variants viral clearance Viral load virus weight loss wild type [DOI] 10.1021/acsnano.2c06350 PMC 바로가기
Immune Response after the Fourth Dose of SARS-CoV-2 mRNA Vaccine Compared to Natural Infection in Three Doses’ Vaccinated Solid Organ Transplant RecipientsArticle Published on 2022-10-192022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] administration analyzed booster booster dose booster doses Breakthrough infection cellular response CLIA Cohort COVID-19 dose Efficacy ELISA ELISpot assay fourth dose General population humoral IgA IgA level IgG immune immune response IMPROVE in both group Infection mRNA mRNA vaccine natural natural infection new SARS-CoV-2 no difference Organ transplant Patient positive recipient recipients repeated response SARS-CoV-2 SARS-COV-2 infection secretion serum IgG severe COVID-19 significant increase significantly increased Solid solid organ transplant Solid organ transplant recipients. Still T cell T-cell T-cell Response Transplant vaccination Vaccine vaccine-induced immune response variants of concern [DOI] 10.3390/v14102299 PMC 바로가기
Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severityArticle Published on 2022-09-072022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Alpha alphacoronavirus antibodies approach betacoronavirus caused coronavirus correlated correlation COVID-19 COVID-19 pandemic COVID-19 severity cross-reactivity Disease progression Donor Endemic endemic human coronavirus healthy controls Humoral immunity IgG response immune response infected individuals marker multiplex multiplex serology nucleocapsid nucleocapsid protein nucleocapsid protein. raise responses against SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome serum serum IgG Stratification understanding Viral antigen were measured [DOI] 10.3389/fimmu.2022.889836 PMC 바로가기
Serum and breastmilk SARS-CoV-2 specific antibodies following BNT162b2 vaccine: prolonged protection from SARS-CoV-2 in newborns and older childrenArticle Published on 2022-09-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] addressed anti-S IgG anti-SARS-CoV-2 antibody BNT162b2 BNT162b2 vaccine Breastfeeding breastmilk children collected COVID-19 determine ELISA enzyme-linked immunosorbent first dose IgA IgG immune response Immunoglobulin G lactating women mother mRNA vaccination mRNA vaccine Newborn Older Patient peaked Prospective Study protection Quantitative analysis SARS-CoV-2 SARS-CoV-2 specific antibody second dose Secretory antibody semi-quantitative serum serum IgG Specific spike transmitted vaccination vaccine. were measured women [DOI] 10.1016/j.ijid.2022.06.055 PMC 바로가기
Antibody response to BNT162b2 SARS-CoV-2 mRNA vaccine in adult patients with systemic sclerosisArticle Published on 2022-09-012022-11-15 Journal: Clinical Rheumatology [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI Affect Antibody titer BNT162b2 CCS Clinical characteristics Cohort Comorbidity Corticosteroids COVID-19 difference disease evaluated Fisher exact test healthy control humoral Humoral response Immunosuppression immunosuppressive Immunosuppressive treatment IQR Logistic regression analysis low dose Mann-Whitney methotrexate mRNA vaccination mRNA vaccine MTX Patient patients patients treated Point reduced Regression model risk RTX SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine second dose serological response seropositive Seropositivity serum IgG severe disease course student systemic Systemic sclerosis t-test therapy Treatment untreated patient vaccination vaccination. Vaccine vaccine-induced antibody [DOI] 10.1007/s10067-022-06219-7 PMC 바로가기
Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine in people living with HIV: A cross-sectional studyHIV 보균자에서 비활성화된 SARS-CoV-2 백신의 면역원성과 안전성: 단면 연구Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Analysis antibody Antiretroviral therapy appear ART CD4+ T cell CD4+ T cells CD4+ T-cell chemiluminescence Chinese control group COVID-19 COVID-19 vaccine cross-sectional delta variant Delta variants detect Efficacy and safety enzyme enzyme immunoassay healthy individual Human immunodeficiency virus IgG IgM antibodies IgM antibody immunoassay immunodeficiency immunogenicity inactivated indicated individual Mild multivariable analysis NAb Neutralizing neutralizing antibody Odds ratio PLWH proportion Safe SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2-specific IgG self-limiting seropositive Seropositivity serum IgG serum levels Side effect Side effects side effects. significantly higher T cells titers vaccination was used wild-type SARS-CoV-2 with HIV [DOI] 10.1002/jmv.27872 PMC 바로가기 [Article Type] Article
Safety and immunogenicity following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a secondary analysis of a randomised, placebo-controlled, phase 2 trialClinical Trial Published on 2022-08-102022-10-06 Journal: The Lancet. Infectious Diseases [Category] SARS, 변종, 진단, [키워드] 1:1 Administered administration adverse event adverse events age amplifying analysed Analysis antibody concentration Antigen assigned available data BMI booster booster dose Breastfeeding Coalition Contraception COVID-19 pandemic diagnosis of COVID-19 dose Efficacy enrolled evaluated event Evidence exclusion geometric mean titre GMT group healthy homologous IgG immune response inactive increase in initial intramuscular Local Matrix-M median Medical conditions Novavax NVX-CoV2373 outcome participant per-protocol per-protocol population phase 2 trial phase 3 study Placebo placebo-controlled pregnant primary endpoint proportion Protein randomisation randomised Randomly reaction reactogenicity receive Recombinant spike protein recruited regimens Registered Safety SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant screened serum IgG single booster dose stratified Support the SARS-CoV-2 the vaccine titres Treatment Trial USA vaccination Vaccine variant were excluded women [DOI] 10.1016/S1473-3099(22)00420-0 PMC 바로가기 [Article Type] Clinical Trial
[Change in serum IgG antibody during the recovery stage of Omicron variant infection in children: an analysis of 110 cases][소아 오미크론 변이체 감염 회복기 혈청 IgG 항체 변화 : 110건 분석]Article Published on 2022-07-152022-09-11 Journal: Zhongguo dang dai er ke za zhi = Chinese journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis antibody BBIBP-CorV Beijing Biological Biological products booster vaccination caused Child children China Chinese citation Clinical data Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diagnosed Diagnosis disease dose doses English four group four groups groups IgG IgG antibody inactivated Inactivated vaccine Infection journal no significant difference no significant differences Nucleic acid detection omicron pediatrics protective effect RBD IgG Recovery stage reduction in respiratory Retrospective analysis route SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 nucleic acid SARS-CoV-2 vaccination SARS-CoV-2 vaccine serum IgG Serum level severe acute respiratory syndrome Coronavirus Sex significant difference significant differences significantly higher significantly lower Sinopharm status the vaccine Tianjin Transmission two group two groups vaccination vaccination. Vaccine variant was performed [DOI] 10.7499/j.issn.1008-8830.2204074 PMC 바로가기 [Article Type] Article
Seroprevalence in health care workers during the later phase of the second wave: Results of three hospitals in Serbia, prior to vaccine administration2차 유행 후반기 의료 종사자의 혈청 유병률: 백신 접종 전 세르비아의 3개 병원 결과Article Published on 2022-07-012022-09-12 Journal: Journal of infection and public health [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adjusted Analysis Anosmia/ageusia Antibody test Belgrade Blood center Characteristics conducted country COVID COVID-19 COVID-19 infection COVID-19 pandemic cross-sectional disease Emergency evaluate Fever HCW HCWs Health care worker Healthcare workers hospital IgG antibody independent predictor later phase multivariate logistic regression outbreak Patient PCR Personal protective equipment positive positive result Prevalence problem public health measure questionnaire Result Risk perception SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 PCR testing second wave Sensitivity and specificity serology Seroprevalence seroprevalence. serum IgG Shortness of breath similar study socio-demographic Symptom tested vaccination vaccine administration [DOI] 10.1016/j.jiph.2022.05.009 PMC 바로가기 [Article Type] Article